Umubare munini wa buffers urakenewe murwego rwo hasi rwo kweza ibinyabuzima. Ukuri no kubyara bya buffer bigira ingaruka zikomeye muburyo bwo kweza poroteyine. Sisitemu yo kumurongo hamwe na sisitemu yo gukuramo kumurongo irashobora guhuza ibice bitandukanye bigize buffers. Inzoga z'ababyeyi na diluent zivanze kumurongo kugirango zibone igisubizo. Igicuruzwa gishingiye ku bumenyi bwa siyansi, kandi ubuziranenge buturuka ku gitekerezo cyo gushushanya (QbD). Binyuze mugihe nyacyo kumurongo (Real in time) gukurikirana no kugenzura ibipimo bibiri bya shimi, ibintu byingenzi biranga ubuziranenge (CQA) byibicuruzwa (CQA), pH hamwe nubushobozi mugihe cyibikorwa, Wiyemeze gutanga bufferi zihamye kandi zihamye ubuziranenge bwibikorwa byo hasi kugirango bifashe ibinyabuzima bikoresha imiti igamije kurekura intego. Inzira gakondo yo gutegura amazi isaba umubare munini wibigega nubunini bunini. IVEN izana abakiriya uburambe bushya bwa tekiniki, kugabanya ikirenge cya dosiye ikoreshwa mugihe cyo kweza, no kugabanya mbere yishoramari na nyuma yumusaruro nigikorwa cyo gukora. , Kunoza imikorere yumusaruro, kwemeza ibipimo byingenzi (CPP) bya buffer hamwe nibishobora gukurikiranwa, kandi amaherezo bizamura ireme ryimiti.