Mubijyanye na biotechnologie hamwe na biofarmaceutical, ijambo "bioreactor" na "biofermenter" rikoreshwa kenshi, ariko ryerekeza kuri sisitemu zitandukanye zifite imikorere nibikorwa byihariye. Gusobanukirwa itandukaniro riri hagati yubwoko bubiri bwibikoresho ningirakamaro kubanyamwuga murwego, cyane cyane mugushushanya no gukora sisitemu yujuje ubuziranenge bukomeye.

Gusobanura Amagambo

Bioreactor nijambo ryagutse rikubiyemo ikintu cyose kibamo reaction ya biologiya. Ibi birashobora kubamo inzira zitandukanye nka fermentation, umuco w'akagari, hamwe na enzyme reaction. Ibinyabuzima bishobora gukorerwa ikirere cyangwa anaerobic kandi birashobora gushyigikira ibinyabuzima bitandukanye, nka bagiteri, umusemburo, n’inyamabere. Bafite ibikoresho bitandukanye byubushyuhe, pH, urwego rwa ogisijeni, hamwe nubugenzuzi bwogukurikirana kugirango bahindure imikurire ya mikorobe cyangwa ingirabuzimafatizo.

Ku rundi ruhande, biofermenter, ni ubwoko bwihariye bwa bioreactor ikoreshwa cyane cyane mubikorwa bya fermentation. Gusembura ni inzira ya metabolike ikoresha mikorobe, cyane cyane umusemburo cyangwa bagiteri, kugirango isukari ibe aside, gaze, cyangwa inzoga.Ibinyabuzima byashizweho kugirango habeho ibidukikije bifasha gukura kwi mikorobe, bityo bikabyara ibinyabuzima bitandukanye nka Ethanol, acide organic, na farumasi.

Itandukaniro nyamukuru

Igikorwa:

Ibinyabuzima birashobora gukoreshwa muburyo butandukanye bwa bioprocesses, harimo umuco w'utugingo ngengabuzima hamwe na reaction ya enzyme, mugihe fermenter yagenewe muburyo bwa fermentation.

Igishushanyo mbonera:
IbinyabuzimaByashizweho kenshi nibintu byihariye kugirango bihuze ibikenerwa bya fermenting. Kurugero, barashobora gushiramo ibintu nka baffles kugirango batezimbere kuvanga, sisitemu yihariye yo guhinduranya aerobic fermentation, hamwe na sisitemu yo kugenzura ubushyuhe kugirango bakomeze ibihe byiza byiterambere.

Gusaba:
Ibinyabuzima bikora byinshi kandi birashobora gukoreshwa mubikorwa bitandukanye mubikorwa bitandukanye, harimo imiti, ibiryo n'ibinyobwa, hamwe nibinyabuzima byangiza ibidukikije. Ibinyuranye na byo, ferment ikoreshwa cyane cyane mu nganda zitanga umusaruro wa fermentation, nko gukora divayi, inzoga, n’ibicuruzwa bikomoka kuri peteroli.

Igipimo:
Byombi bioreactors na fermenters birashobora gushushanywa mubipimo bitandukanye, kuva mubushakashatsi bwa laboratoire kugeza kumusaruro winganda. Nyamara, fermenters mubusanzwe ifite ubushobozi bunini bwo kwakira ibicuruzwa byinshi byakozwe mugihe cyo gusembura.

Uruhare rwa GMP na ASME-BPE mugushushanya fermenter

Kubahiriza ibipimo ngenderwaho nibyingenzi mugihe cyo gushushanya no gukorabio-fermenters. Kuri IVEN, turemeza ko fermenter zacu zateguwe kandi zakozwe muburyo bwubahiriza amabwiriza meza yo gukora neza (GMP) hamwe na ASME-BPE (Sosiyete y'Abanyamerika y'Abashinzwe Imashini - Ibikoresho bya Bioprocessing). Uku kwiyemeza ubuziranenge n'umutekano ni ingenzi kubakiriya bacu ba biofarmaceutical bishingira ibikoresho byacu kugirango fermentation ya mikorobe.

Iwacuibigega bya fermentationibiranga ubuhanga, umukoresha-mwiza kandi wuburyo bushobora kwinjizwa byoroshye muri sisitemu zihari. Dutanga ubwato bwujuje ubuziranenge bwubwato butandukanye bwigihugu, harimo ASME-U, GB150 na PED (Amabwiriza y’ibikoresho byingutu). Iyi mpinduramatwara yemeza ko tanks zacu zishobora kwakira ibintu byinshi bisabwa hamwe nibisabwa n'amategeko.

Guhindura no Guhindura

Kuri IVEN, twumva ko buri mukiriya wa biopharmaceutical afite ibyo akeneye bidasanzwe. Niyo mpamvu dutanga fermenter zose zo guhinga mikorobe, kuva muri laboratoire R&D kugeza ku nganda n’inganda. Fermenters yacu irashobora guhindurwa kubisabwa byihariye, harimo n'ubushobozi, kuva kuri litiro 5 kugeza kuri kilo 30. Ihinduka ridufasha guhaza ibikenerwa na bagiteri zo mu kirere cyane, nka Escherichia coli na pastoris ya Pichia, zikoreshwa cyane mu musaruro w’ibinyabuzima.

Muncamake, mugihe byombi bioreactors nabiofermentersGira uruhare runini mubijyanye na biotechnologiya, bikoreshwa mubikorwa bitandukanye kandi byateguwe nibikorwa bitandukanye mubitekerezo. Gusobanukirwa itandukaniro nibyingenzi muguhitamo ibikoresho bikwiye kubisabwa byihariye. Muri IVEN, twiyemeje gutanga fermenter nziza-yujuje ibyangombwa bisabwa ninganda zikomoka ku binyabuzima, tukareba ko abakiriya bacu bashobora kugera ku musaruro mwiza mubikorwa byabo byo guhinga mikorobe. Waba uri mubyiciro byambere byubushakashatsi cyangwa kwagura umusaruro winganda, ubuhanga bwacu nibisubizo byihariye birashobora kugufasha kwigirira icyizere kugendana na bioprocessing.