Mu ishami ry’ikoranabuhanga mu by’ibinyabuzima n’imiti ikoreshwa mu by’ibinyabuzima, amagambo "bioreactor" na "biofermenter" akunze gukoreshwa mu buryo butandukanye, ariko yerekeza ku buryo butandukanye bufite imikorere n’ikoreshwa ryihariye. Gusobanukirwa itandukaniro riri hagati y’ubwo bwoko bubiri bw’ibikoresho ni ingenzi ku banyamwuga muri urwo rwego, cyane cyane iyo bashushanya kandi bagakora sisitemu zujuje ibisabwa n’amategeko.

Amagambo asobanura

Bioreactor ni ijambo ryagutse rikoresha ikintu icyo ari cyo cyose gikorerwamo ingaruka z’ibinyabuzima. Ibi bishobora kuba birimo inzira zitandukanye nko guhinga, guteza imbere ingirabuzimafatizo, n’imikorere ya enzyme. Bioreactor zishobora gukorerwa mu bihe byo kuzura cyangwa kutagira umwuka kandi zishobora gushyigikira ibinyabuzima bitandukanye, harimo bagiteri, umusemburo, n’uturemangingo tw’inyamabere. Zifite ubushyuhe butandukanye, pH, urwego rwa ogisijeni, n’uburyo bwo kugenzura uburyo bwo gukura bw’uturemangingo cyangwa uturemangingo.

Ku rundi ruhande, biofermenter ni ubwoko bwihariye bwa bioreactor bukoreshwa cyane cyane mu mikorere yo guhinga. Gushyunga ni inzira yo guhindura imikorere y’umubiri ikoresha mikorobe, cyane cyane umusemburo cyangwa bagiteri, kugira ngo isukari ihindurwemo aside, imyuka, cyangwa alcool.Abahinzi b'ibinyabuzima byagenewe gushyiraho ibidukikije bifasha mu gukura kw'utu dukoko, bityo bikabyara ubwoko butandukanye bw'ibikomoka kuri bioproducts nka ethanol, aside organic, n'imiti.

Itandukaniro ry'ingenzi

Imikorere:

Bioreactors zishobora gukoreshwa mu buryo butandukanye bwa bioprocesses, harimo culture y'uturemangingo n'imikorere ya enzymes, mu gihe fermenters zagenewe by'umwihariko inzira zo guhinga.

Ibisobanuro by'igishushanyo:
Abahinzi b'ibinyabuzimaakenshi zikozwe zifite imiterere yihariye kugira ngo zihuze n'ibyo ibinyabuzima bitera umusemburo bikenewe. Urugero, zishobora kuba zirimo ibintu nka baffles kugira ngo zinoze kuvanga, sisitemu zihariye zo guhumeka umwuka kugira ngo fermentation ikoreshwe, hamwe na sisitemu zo kugenzura ubushyuhe kugira ngo zikomeze gukura neza.

Porogaramu:
Bioreactors zikoreshwa mu buryo butandukanye kandi zishobora gukoreshwa mu bikorwa bitandukanye mu nganda zitandukanye, harimo imiti, ibiribwa n'ibinyobwa, ndetse n'ikoranabuhanga mu bidukikije. Mu buryo bunyuranye, fermenters zikoreshwa cyane cyane mu nganda zikora ibintu bishyushya, nko gukora divayi, guteka, no gukora lisansi ya biofuel.

Igipimo:
Imashini zitunganya ibinyabutabire n'izitunganya ibinyabutabire zishobora gutegurwa ku bipimo bitandukanye, kuva ku bushakashatsi bwo muri laboratwari kugeza ku musaruro w'inganda. Ariko, imashini zitunganya ibinyabutabire akenshi ziba zifite ubushobozi bunini bwo kwakira umusaruro mwinshi usanzwe ukorwa mu gihe cyo gutwika ibinyabutabire.

Uruhare rwa GMP na ASME-BPE mu gushushanya fermenter

Gukurikiza amabwiriza agenga imiterere n'ikorwa ryabyo ni ingenzi cyane iyo bigeze ku gishushanyo mbonera n'ikorwa ryabyo.ibikomoka ku bimeraMuri IVEN, twemeza ko imashini zacu zo gushyushya zikozwe kandi zigakorwa hakurikijwe amabwiriza agenga ikoreshwa rya GMP n'ibisabwa na ASME-BPE (Umuryango w'Abanyamerika w'Abahanga mu by'Ubwubatsi bw'Imiterere - Ibikoresho byo Gutunganya Ibikoresho). Uku kwiyemeza ubuziranenge n'umutekano ni ingenzi ku bakiriya bacu ba biopharmaceutical bishingikiriza ku bikoresho byacu mu gushyushya mikorobe.

Ibyacuibigega byo guhishaIfite imiterere y’umwuga, yoroshye kuyikoresha kandi ishobora gushyirwa mu buryo bworoshye muri sisitemu zisanzweho. Dutanga amato yujuje ibisabwa n’amabwiriza atandukanye y’igihugu y’amato y’umuvuduko, harimo ASME-U, GB150 na PED (Amabwiriza y’ibikoresho by’umuvuduko). Ubu buryo bworoshye butuma amato yacu ashobora kwakira ibintu bitandukanye n’amabwiriza agenga ikoreshwa ryayo.

Guhindura no Guhindura Ibintu mu buryo butandukanye

Muri IVEN, turasobanukiwe ko buri mukiriya wa biopharmaceutical afite ibyo akeneye byihariye. Niyo mpamvu dutanga ubwoko bwose bw'ibikoresho byo guhinga mikorobe, kuva ku bushakashatsi n'iterambere bya laboratwari kugeza ku musaruro w'inganda. Ibikoresho byacu byo guhinga bishobora guhindurwa hakurikijwe ibisabwa byihariye, harimo n'ubushobozi, kuva kuri litiro 5 kugeza kuri kilolitiro 30. Ubu buryo bworoshye butuma duhura n'ibyo bagiteri zikenera cyane, nka Escherichia coli na Pichia pastoras, zikunze gukoreshwa mu gukora biopharmaceutical.

Muri make, mu gihe bioreactors naabahinga b'ibinyabuzimabigira uruhare runini mu bijyanye n'ikoranabuhanga mu binyabuzima, bikoreshwa mu ntego zitandukanye kandi byakozwe hifashishijwe imikorere itandukanye. Gusobanukirwa izi tandukaniro ni ingenzi mu guhitamo ibikoresho bikwiye gukoreshwa mu buryo bwihariye. Muri IVEN, twiyemeje gutanga imashini zitunganya ibinyabutabire nziza zujuje ibisabwa bikomeye n'inganda zitunganya ibinyabutabire, tukareba ko abakiriya bacu bashobora kugera ku musaruro mwiza mu mikorere yabo yo guhinga mikorobe. Waba uri mu ntangiriro z'ubushakashatsi cyangwa wongere umusaruro w'inganda, ubuhanga bwacu n'ibisubizo bihinduka bishobora kugufasha guhangana n'ingorane zo gutunganya ibinyabutabire mu binyabuzima.